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WO2017099823A1 Compositions and methods for delivery of

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US10207010B2 - Compositions and methods for delivery of .

US10207010B2 - Compositions and methods for delivery of ...

WO/2009/086558 IMPROVED COMPOSITIONS AND METHODS FOR THE .

The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective ...

WO2017099823A1 - Compositions and methods for delivery of .

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

NOVEL NUCLEIC ACID MOLECULES - CUREVAC

The present invention provides novel artificial nucleic acid molecules encoding at least one antigenic peptide or protein and at least one additional sequence preferably targeting the antigenic peptides or proteins to cellular compartments of interest. Further, the invention provides (pharmaceutical) compositions or vaccines and kits comprising said nucleic acid molecules.

WO2017099823A1 - Compositions and methods for delivery of .

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

COMPOSITIONS AND METHODS FOR NON-PARENTERAL DELIVERY OF .

The present invention relates to compositions and methods which enhance the local and systemic uptake and delivery of oligonucleotides and nucleic acids via non-parenteral routes of administration. Pharmaceutical compositions comprising oligonucleotides disclosed herein include, for systemic ...

US Patent for Compositions and methods for delivery of .

Described herein are compositions comprising particles of poorly soluble drugs encapsulated by stabilizers. Further described are pharmaceutical compositions comprising such encapsulated compositions. Also described are methods of making such encapsulated particle compositions, and methods of making the corresponding pharmaceutical compositions.

Compositions and methods for systemic delivery of oral .

The invention includes compositions and methods for oral delivery of antigen or therapeutic agent in the total blood flow using a modified botulinum toxin, which is modified using the modification or deletion of one of the amino acids: His(229), Glu(230) and His(223), which is able to transloziruetsa from the intestines to the overall flow, but ...

NOVEL NUCLEIC ACID MOLECULES - CUREVAC

The present invention provides novel artificial nucleic acid molecules encoding at least one antigenic peptide or protein and at least one additional sequence preferably targeting the antigenic peptides or proteins to cellular compartments of interest. Further, the invention provides (pharmaceutical) compositions or vaccines and kits comprising said nucleic acid molecules.

Compositions and methods for delivery of materia

Compositions for the controlled delivery of active ingredients, for example, drugs, cosmetic materials, and agricultural materials. The compositions include a multiplicity of particles, each of the particles comprising (1) a microstructure comprising a semicrystalline polymer which has a peak melting temperature, Tp, of at least 20° C., and (2) the active ingredient.

COMPOSITIONS AND METHODS FOR DELIVERY OF GENETIC MATERIAL .

Methods of introducing genetic material into cells of an individual and compositions and kits for practicing the same are disclosed. The methods comprise the steps of contacting cells of an individual with a polynucleotide function enhancer and administering to the cells, a nucleic acid molecule that is free of retroviral particles.

Compositions and Methods for Non-Toxic Delivery of .

Compositions of the present invention may also be formulated for transdermal delivery, for example as a cream, ointment, lotion, paste, gel, medicated plaster, patch, or membrane. Such compositions can comprise any suitable excipients, for example penetration enhancers and the like.

US10207010B2 - Compositions and methods for delivery of .

US10207010B2 - Compositions and methods for delivery of ...

Compositions and methods for delivery of biologically .

The present invention provides methods and compositions for the delivery of a biologically active agent to a biological system. The compositions include the active agent and a lyotropic phase and release of the active agent to the biological system is modified by the lyotropic phase.

WO2017099823A1 - Compositions and methods for delivery of .

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

US20180271777A1 - Compositions and Methods for the .

The present invention relates to methods and compositions for the delivery of cosmetics and medicants. In some embodiments, the invention relates to compositions comprising both hydrophobic and hydrophilic polymers. In preferred embodiments, the invention relates to the delivery of peptides, small molecules and other bioactive compounds using the compositions and methods disclosed herein.