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CA2473572C Quinazoline compounds Google Patents

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Quinazoline derivatives as anticancer drugs: A patent .

Request PDF on ResearchGate | Quinazoline derivatives as anticancer drugs: A patent review (2011-present) | Introduction: Quinazoline is one of the most studied moieties in medicinal chemistry due ...

C07D - Heterocyclic compounds - Patents Sitemap - google.c

US8486955 Anti-cancer cyclopenta [g] quinazoline compounds 07/09/2013 US8481478 Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using ...

CA2473572C - Quinazoline compounds - Google Paten

The invention relates to compounds of the formula (IId): (See formula IId) their use in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warmblooded animals; processes for the preparation of such compounds; intermediates used in such processes; processes for making such intermediates; pharmaceutical compositions ...

An alternative synthesis of Vandetanib (Caprelsa™) via a .

The key Dimroth rearrangement step was then investigated commencing from 10 in the presence of 4-bromo-3-fluoroaniline (1 equiv.) and acetic acid with microwave heating at 130 °C for 45 min. No product was observed by either TLC or LCMS when irradiated for 15 minutes at 118 °C; this contrasted with previous reports on the synthesis of related 4-anilinoquinazolines such as Gefitinib.15, 16 ...

CA2473572A1 - Quinazoline compounds - Google Paten

The compounds of formula I inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis. ...

Potent and Selective Covalent Quinazoline Inhibitors of .

Zeng et al. demonstrate that introduction of an amino amide substituent to the quinazoline scaffold remarkably increases the labeling efficiency and rates, potency, and selectivity of KRAS G12C inhibitors. This is supported by structural evidence that amide side chain allows additional interactions with KRAS G12C.

Synthesis of some novel dibromo-2-arylquinazolinone .

Huang KH, Veal J, Barta T, Smith ED, Ma W, Ommen A. Quinazoline derivatives for the treatment of cancer. Google Patents EP3173084A1, 2010. Arnold LD. 4-heterocyclyl-substituted quinazoline derivatives, processes for their preparation and their use as anti-cancer agents. Google Patents US5736534A, 1998.

CA2473572A1 - Quinazoline compounds - Google Paten

The compounds of formula I inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis. ...

Quinazoline cardiovascular agents (review .

The advances in the search for biologically active quinazoline compounds and medicinal preparations created on the basis of them have been reflected in several hundred patents that have been published in this period (see a previous review [28]) and in a large number of original papers and series of published reviews [4, 19, 20, 28-31].

CA2473572C - Quinazoline compounds - Google Paten

The invention relates to compounds of the formula (IId): (See formula IId) their use in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warmblooded animals; processes for the preparation of such compounds; intermediates used in such processes; processes for making such intermediates; pharmaceutical compositions ...

CA2473572C - Quinazoline compounds - Google Paten

The invention relates to compounds of the formula (IId): (See formula IId) their use in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warmblooded animals; processes for the preparation of such compounds; intermediates used in such processes; processes for making such intermediates; pharmaceutical compositions ...

Quinazoline-2,4-diamine | C8H8N4 - PubCh

A three-dimensional representation of the compound. The 3D structure is not experimentally determined, but computed by PubChem. More detailed information on this conformer model is described in the PubChem3D thematic series published in the Journal of Cheminformatics. Read more...

A61P - Specific therapeutic activity of chemical compounds .

More topics under "A61P - Specific therapeutic activity of chemical compounds or medicinal preparations" (2,008,710) A61P 1 - Drugs for disorders of the alimentary tract or the digestive system ...

CA2473572A1 - Quinazoline compounds - Google Paten

The compounds of formula I inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis. ...