logo

PKR a p53 target gene plays a crucial role in the tumor

If you want to confirm some technical details before you order,
just need to send a message or e-mail: [email protected].
Then our professional sales staff will contact you within 2 hours.

(PDF) Dual Role of p53 in Innate Antiviral Immuni

a novel p53 target gene, suggesting that PKR could also play a role in p53-dependent induction of apoptosis upon viral infection [25]. An intriguing unresolved question is whether TNF-related ...

p53 Is a Master Regulator of Proteostasis in SMARCB1 .

Our study sheds light on the crucial role of the tumor suppressor gene TP53 in the regulation of global protein metabolism and in the adaptation to ER stress in the ... PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53. ... In the context of tumor initiation, p53 signaling plays an antiproliferative and tumor ...

PKR, a p53 target gene, plays a crucial role in the tumor .

Abstract. Type I IFN-induced expression of dsRNA-activated protein kinase (PKR) during viral infection is a well-established antiviral mechanism.However, little is known about the expression of PKR in the context of p53 and about PKR involvement in p53-mediated tumor suppression. Here, we report that PKR is a p53 target gene and plays an important role in the tumor-suppressor function of p53.

PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p5

Here, we report that PKR is a p53 target gene and plays an important role in the tumor-suppressor function of p53. Activation of p53 by genotoxic stress induces a significant level of PKR expression by acting on the newly identified cis-acting element (ISRE), which is separated from the IFN-stimulated responsive element on the PKR promoter ...

NAVER Academic > PKR, a p53 target gene, plays a crucial .

PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53. Author Cheol-Hee Yoon, Eun-Soo Lee, Dae-Seog Lim, Yong-Soo Bae Publisher in 2009

Increased Expression of the dsRNA-Activated Protein Kinase PKR in Breast Cancer Promotes Sensitivity to Doxorubic

It has been reported that the expression and activity of the interferon-inducible, dsRNA-dependent protein kinase, PKR, is increased in mammary carcinoma cell lines and primary tumor samples. To extend these findings and determine how PKR signaling may affect breast cancer cell sensitivity to chemotherapy, we measured PKR expression by immunohistochemical staining of 538 cases of primary ...

PKR, a p53 target gene, plays a crucial role in the tumor .

Here, we report that PKR is a p53 target gene and plays an important role in the tumor-suppressor function of p53. Activation of p53 by genotoxic stress induces a significant level of PKR expression by acting on the newly identified cis-acting element (ISRE), which is separated from the IFN-stimulated responsive element on the PKR promoter ...

Zebularine inhibits tumorigenesis and stemness of .

The tumor suppressor p53 is maintained at low level in unstressed cells by MDM2 which ubiquitinates p53 and promotes its degradation. ... D. S. & Bae, Y. S. PKR, a p53 target gene, plays a crucial ...

Clinical and therapeutic potential of protein kinase PKR .

Cuddihy, A.R. et al. (1999) The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro. ... (2015) PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53. Proceeding of the National Academy of Sciences 106 ...

PKR, a p53 target gene, plays a crucial role in the tumor .

Type I IFN-induced expression of dsRNA-activated protein kinase ( PKR ) during viral infection is a well-established antiviral mechanism. However, little is known about the expression of PKR in the context of p53 and about PKR involvement in p53-mediated tumor suppression. Here, we report that PKR is a p53 target gene and plays an important role in the tumor-suppressor function of p53 .

PKR | SpringerLi

Double-stranded RNA-activated protein kinase; dsRNA-activated inhibitor (DAI); Eukaryotic initiation factor 2α (EIF2α) protein kinase 2 (EIF2AK2); Interferon-inducible EIF2α kinase; Interferon-inducibl...

Negative regulation of tumor suppressor p53 by microRNA .

INTRODUCTION The tumor suppressor p53 plays a crucial role in maintaining genomic stability and preventing tumor formation ... PKR, a p53 target gene, plays a crucial ...

PKR, a p53 target gene, plays a crucial role in the tumor .

PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53 Article (PDF Available) in Proceedings of the National Academy of Sciences 106(19):7852-7 · June 2009 with 95 ...

Negative Regulation of Tumor Suppressor p53 by MicroRNA .

Tumor suppressor p53 plays a central role in tumor prevention. p53 protein levels and activity are under a tight and complex regulation in cells to maintain the proper function of p53. MicroRNAs play a key role in the regulation of gene expression. Here we report the regulation of p53 through miR-504. miR-504 acts as a negative regulator of human p53 through its direct binding to two sites in ...

NAVER Academic > PKR, a p53 target gene, plays a crucial .

PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53. Author Cheol-Hee Yoon, Eun-Soo Lee, Dae-Seog Lim, Yong-Soo Bae Publisher in 2009

Negative Regulation of Tumor Suppressor p53 by MicroRNA .

Tumor suppressor p53 plays a central role in tumor prevention. p53 protein levels and activity are under a tight and complex regulation in cells to maintain the proper function of p53. MicroRNAs play a key role in the regulation of gene expression. Here we report the regulation of p53 through miR-504. miR-504 acts as a negative regulator of human p53 through its direct binding to two sites in ...

p53 - Wikiped

In addition to the full-length protein, the human TP53 gene encodes at least 15 protein isoforms, ranging in size from 3.5 to 43.7 kDa. All these p53 proteins are called the p53 isoforms. The TP53 gene is the most frequently mutated gene (>50%) in human cancer, indicating that the TP53 gene plays a crucial role in preventing cancer formation.

Oncogenes: The Passport for Viral Oncolysis Through PKR .

The transforming properties of oncogenes are derived from gain-of-function mutations, shifting cell signaling from highly regulated homeostatic to an uncontrolled oncogenic state, with the contribution of the inactivating mutations in tumor suppressor genes P53 and RB, leading to tumor resistance to conventional and target-directed therapy.

The impact of PKR activation: from neurodegeneration to .

Whereas PKR is recognized for its negative effects on neurodegenerative diseases, in part, inducing high level of apoptosis, the role of PKR activation in cancer remains controversial. In general, PKR is considered to have a tumor suppressor function, and some clinical data show a correlation between suppressed or inactivated PKR and a poor ...

Regulation of innate immunity through RNA structure and .

A recent report suggested that p53-mediated tumor suppression can be attributed to p53's induction of PKR under genotoxic conditions , while another study indicated that PKR regulates insulin action and metabolism in response to nutrient signals and endoplasmic reticulum stress . RNA primary structure-based regulation of PKR